HSPB1 and liver dysplastic nodule: However, in DBA2J mice with Stz-DM, despite pharmacodynamic proof of exposure to orally administered curcumin by timed urine collections measuring excreted curcuminoids, curcumin attenuated the HSP25 response to Stz-DM, increased urinary 12-HETE excretion, and failed to attenuate the albuminuria of DN.