HSPB1 and liver dysplastic nodule: We performed experiments to determine whether curcumin activates the p38MAPK -HSP25-actin cytoskeletal pathway in glucose-stimulated podocytes in vitro, and whether it attenuates diabetic nephropathy (DN) in vivo in mice in whom feeding was begun either before or 1 week after the induction of Stz-DM.