PIK3CA and neoplasm: If we stratify for patients with a mutant primary tumor, 81% of the recurrences were also mutant and the individual frequencies were 75% (98/130) for FGFR3, 23% (30/130) for PIK3CA, and 10% (13/130) for RAS. Interestingly, there was a 100% consistency in the type of mutation for RAS and PIK3CA among different tumors of the same patient.