The activated form of JNK phosphorylated on T183 and Y185 was increased in RVFV-infected HSAECs initially and then dramatic dephosphorylation was observed (more then 10-fold at 72 h.p.i. in comparison with 48 h.p.i) by the higher dose of infection, indicating that it is one of the major RVFV targets. This evidence concerns the gene MAPK8 and infection.