Li et al also examined associations of pancreatic cancer with selected DNA repair polymorphisms in other types of DNA repair pathways, including XRCC2, XRCC3,33RAD54L, and RecQ1 in the recombination repair pathway,34 and the xeroderma pigmentosum group D (XPD) in the NER pathway.35 They found that variant alleles of XRCC2 R188H and XRCC3 A17893G were associated with significantly reduced survival in pancreatic cancer patients and that XRCC2 Arg188His polymorphisms may be genetic modifiers for smoking-related pancreatic cancer. The gene discussed is ERCC2; the disease is familial pancreatic carcinoma.