NAT2 and familial pancreatic carcinoma: (2) The rare NAT1*10 or NAT1*11-NAT2*6A diplotype may be an “at-risk” genetic variant for pancreatic cancer.22 (3) The GSTP1*C variant conferred a possible protective effect against pancreatic cancer.23 (4) A significant interaction was noted between CYP1A2, NAT1, and heavy smoking and dietary mutagen intake.24