Moreover, although IFN alpha was seen to induce changes in miRNA expression in patients with CHC, and that the highest increase in each miRNA was seen only in responder patients, no significant differences were found in the expression levels of IFN-induced miRNAs between responders and non-responders, and HCV-RNA levels appeared to have no influence on the baseline expression of IFN-induced miRNAs. Here, IFNA1 is linked to cryohydrocytosis.