Pre- and post-ACTH cortisol concentrations in the dogs affected with PDH were 4.6 ± 2.9 (ranging from 1.9 to 14.1) and 25.5 ± 11.6 (ranging from 21.6-63.1) μg/dL, respectively (Table 2). This evidence concerns the gene POMC and pyruvate dehydrogenase deficiency.