Moreover, 25-OHC in combination with IL-1β has been shown to stimulate human colon carcinoma cells (Caco-2) to produce IL-8 [38], which in turn is a promoter of angiogenesis by stimulating endothelial cells proliferation, survival, migration, and MMP-2 production [39,40]. This evidence concerns the gene MMP2 and colon carcinoma.