Previously we showed that Aβ oligomers levels in the 3×Tg-AD mice peak at 6 months of age and are significantly lower at 12 months of age [44], which is consistent with the hypothesis that the increased TDP-43 levels in 6-month-old 3×Tg-AD mice may be due to high levels of Aβ oligomers. The gene discussed is TARDBP; the disease is Alzheimer disease.