To investigate the link between Aβ, tau and TDP-43, we first measured the steady-state levels of TDP-43 and its C-terminal fragments in the low salt fraction (see material and methods) of proteins extracted from in 2-, 6-, and 12-month-old 3×Tg-AD and NonTg mice (n = 6/genotype/time-point). This evidence concerns the gene TARDBP and Alzheimer disease.