TARDBP and Alzheimer disease: Linear regression analysis indicated that the levels of AT270 in the brains of 6-month-old 3×Tg-AD mice do not correlate with the levels of TDP-43 and TDP-35 (Figure 4D-E; r2 = 0.09148, p = 0.56; and r2 = 0.1491, p = 0.45, respectively).