TARDBP and Alzheimer disease: We found that in 6-month-old 3×Tg-AD mice, A11-positive Aβ oligomers positively correlated with TDP-43 (r2 = 0.9330, p = 0.001; Figure 5G) and TDP-35 (r2 = 0.6749, p = 0.045; Figure 5H).