TARDBP and Alzheimer disease: Taken together, these data indicate that the higher levels of TDP-43 and TDP-35 in the brains of 6-month-old 3×Tg-AD mice compared to NonTg mice are due to an increase of these proteins in the 3×Tg-AD mice as a function of age and not to a decrease of the levels of TDP-43 and TDP-35 in the brains of NonTg mice.