Ourin vivo NMR results showed reduced ATP synthesis rate in tumor-bearing(TB) mice relative to control (C) mice, and were cross-validated with whole genometranscriptome data showing atypical expression levels of skeletal muscle regulatory genessuch as peroxisomal proliferator activator receptor γ coactivator 1 ß(PGC-1ß), a major regulator of mitochondrial biogenesis and, mitochondrialuncoupling protein 3 (UCP3). This evidence concerns the gene PPARGC1A and neoplasm.