PPARGC1A and cancer: This finding is consistentwith a previous report suggesting that PGC-1s inhibit FoXOs-dependent transcription (53) and provides support for the viewthat PGC-1ß may play a central regulatory role in cancer-induced cachexia given thatFoXOs are involved in multiple signaling pathways and play critical roles in numerousphysiological and pathological processes including cancer (64).