The hypothesis that IGF-1/AKT attenuation contributes to cancer cachexia is supported bythe presently observed elevated levels of the EIF4Ebp1 in TB mice, as EIF4Ebp1 levels havebeen found to correlate with cancer development and cachexia (71,72) due to inhibition of protein synthesis (73) via binding to eukaryotic initiationfactor 4E (eIF4E) (74). The gene discussed is EIF4E; the disease is cancer.