A principal finding of the present study was that down-regulation of PGC-1ß in TBmice was accompanied by a down-regulation of SOD2 as well as an upregulation of GPX.Interestingly, it has previously been shown that PGC-1s increase gene expression of SOD2,GPX and enzymes responsible for glutathione biosynthesis (24), and both SOD2 and GPX have been implicated in cancer-inducedoxidative stress response (61–63). Here, PPARGC1A is linked to cancer.