IGF1 and cancer: Moreover, if PGC-1s mediatekey regulatory functions in cancer-induced cachexia as suggested by the present findings,they could serve as funnels where several oncogenic/cachectic signals (cytokines, ROS,IGF-1) converge to drive the downstream physiological response (mitochondrial dysfunction,antioxidative and immune-inflammatory response, protein synthesis and degradation) ofskeletal muscle to malignancy.