The ratios of CD4+ CXC chemokine receptors (CXCR)3+/CD4+CCR3+ indicating Th1/Th2 and CD8+CXCR3+/CD8+CCR4+ indicating cytotoxic T (Tc) 1/Tc2 was significantly higher only in MS patients. This evidence concerns the gene CCR4 and myeloid sarcoma.