Several studies have reported Th1 dominance over the Th2 response associated with chemokine receptors in MS, increased percentages of T cells expressing CXCR3 and CCR5 chemokine receptors on PBL and cerebrospinal fluid (CSF) in the active phase of MS and the identification of CXCR3+ and CCR5+ T cells in active demyelinating MS brain lesions [2,3]. The gene discussed is CXCR3; the disease is myeloid sarcoma.