In addition, some studies have reported that low levels of TopIIα gene or protein expression might be related with resistance not only to TopII inhibitors, such as etoposide and anthracycline, but also to other cytotoxic drugs, such as cisplatin, microtubule-interacting agents and gemcitabine, in some cancer cell lines or cancers [17-19]. The gene discussed is TOP2A; the disease is cancer.