ASGR1 and autoimmune hepatitis: In relatives of patients with AIH, Vento et al [21] demonstrated an intrinsic defect in suppressor-inducer T-cells mediating immune reactivity to a liver antigen (asialoglycoprotein receptor-ASPGR), and described the development of AIH following sub-clinical exposure (seroconversion to HAV) with a simultaneous rise in anti-ASGPR antibodies.