A putative transcription factor binding site of the HTRA1 gene in the 10q26 region was shown to confer significant risk for choroidal neovascularization in age related macular degeneration (AMD) and SNPs rs1061170, rs3753394 in CFH and rs10490924 in ARMS2/LOC387715 showed significant association [35-40]. This evidence concerns the gene HTRA1 and age-related macular degeneration.