Dermatitis, alopecia, and nail defects are also associated with zinc deficiency.[4] Acrodermatitis enteropathica develops in a zinc-deficient patient and a combined nutritional deficiency of zinc, EFAs, albumin and amino acids may result in acrodermatitis enteropathica.[14] The activities of lysyl oxidases that initiate the cross-linking of collagen and elastin decline with copper deficiency.[15] Chronic iron deficiency has resulted in spoon shaped nails (koilonychia), hair loss, glossitis with loss of papillae, angular cheilitis, and pruritus.[4]. This evidence concerns the gene ALB and acrodermatitis enteropathica.