CDH1 and gastric cancer: Such a disruption can be achieved by downregulating the expression of cadherin family members, in particular E-cadherin, whose importance in maintenance of normal cell architecture is supported by the observation that hereditary predisposition to gastric cancer is associated with germ line mutation in the gene encoding for E-cadherin (Hirohashi, 1998) or that lobular breast carcinomas frequently show mutation of CDH1 gene with a decreased E-cadherin expression (Qureshi et al, 2006).