For example, Hazan et al (2000) have shown that the non-metastatic breast cancer cell line MCF7 can be transformed in a metastatic cell line when transfected with N-cadherin and that when injected into the mammary fat pad of nude mice, these N-cadherin-expressing cells metastasised to visceral organs whereas control MCF7 cells did not. This evidence concerns the gene CDH2 and breast carcinoma.