CDH1 and invasive carcinoma: In fact, although a low expression of E-cadherin has been found in invasive carcinomas without metastases, high E-cadherin levels have been observed in nodal metastases as compared with their primary tumour (Beavon, 2000; Kowalski et al, 2003; Harigopal et al, 2005; Jeschke, 2007).