CDH1 and neoplasm: Consistently, the downregulation of E-cadherin has been found correlated with short disease-free survival and poor outcome in many tumour from epithelial origin, including breast cancer (Asgeirsson et al, 2000; Heimann et al, 2000; Berx and Van Roy, 2001; Lim and Lee, 2002; Pedersen et al, 2002; Rakha et al, 2005; Gould Rothberg and Bracken, 2006).