AKT1 and neoplasm: Downregulation of both Ras/MEK pathway and PI3K/AKT pathway may have synergistic effects in inducing tumour angiogenesis (Jiang and Liu, 2008), and with NF-κB downregulation, a potent inhibition of tumour angiogenesis can be expected after FGF2-targeted Ad-NBS1 transduction.