This FGF2-targeted adenoviral system has achieved efficient gene transfer in previously reported ovarian, pancreatic, skin and lung cancer models, as well as in HNSCC and in endothelial cells (ECs) (Rogers et al, 1997; Rancourt et al, 1998; Kleeff et al, 2002; Qin et al, 2005; Saito et al, 2009). Here, FGF2 is linked to head and neck squamous cell carcinoma.