TNFSF10 and cancer: Indeed, when TRAIL was not expressed with doxycycline, the use of mitoxantrone alone did not significantly increase the early and late apoptotic cancer cells, consistent with a degree of mitoxantrone chemoresistance of the SP cells as discussed above (33.9±2.4% with mitoxantrone compared with 24.56±4.2% without mitoxantrone) (P>0.05, Anova) (Figure 4F).