In breast cancer, presence of a novel 4 bp insertion in the TGFβ2 promoter, which leads to increased promoter activity, was shown to be associated with lymph node metastasis (Beisner et al, 2006), suggesting that the TGFβ2 isoform may contribute to breast cancer metastasis through induction of EMT in mammary epithelial cells. The gene discussed is TGFB2; the disease is metastatic malignant neoplasm in the lymph nodes.