A single study assessed the prognostic significance of Cathepsin D in anal cancer, and although 50% of tumours were Cathepsin D positive, the investigators found no correlation with overall survival (P>0.10) or with the clinicopathological parameters of tumour stage, tumour differentiation or lymph node involvement (Table 6) (Holm and Tanum, 1996). The gene discussed is CTSD; the disease is anal carcinoma.