Several clusters of genes in our profile are oncogenic molecules contributing to cancer development, for example, E2F genes (Hurst et al, 2008), insulin-like growth factors (Huszar et al, 2009), cell division cycle genes (Chen et al, 2006), α-/β-tubulines (Canta et al, 2009), and zinc finger proteins (Gommans et al, 2005; Supplementary Table SIII). The gene discussed is ZNF146; the disease is cancer.