CCND1 and breast cancer: Several oncogenes on the gained loci were identified in BC in the previous array-CGH studies; for example, CCND1, a member of cyclinD1, FGF3/4, fibroblast growth factors and EMS1, a regulator of cell adhesion are located on 11q13 (Zaharieva et al, 2003); E2F3, a transcription factor positively regulating cell cycle, is located on 6p22 (Hurst et al, 2008); and KLK5, a serine protease involved in cancer progression, is located on 19q13.3 (Shinoda et al, 2007).