With regards to the aggressiveness of CLL, the RelA member of the NF-κB family, involved in its heterodimeric form with p50 and through its temporal transactivation of "regulon" type genes in a canonical manner, has been recently reported to be associated with both in vitro survival and clinical disease progression in CLL. The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.