SOD1 and amyotrophic lateral sclerosis: Recently, inclusions with misfolded SOD-1 forms [4] and a wild-type SOD-1 sharing aberrant conformation and pathogenic pathway with mutant SOD-1 [5] have also been identified in sporadic ALS spinal cord motor neurons, suggesting the possibility that misfolded SOD-1 auto antigens stimulate inflammation in sporadic ALS as well.