Healthy endothelial cells have the ability to prevent excess expression of adhesion molecules, resist increases in LDL and cholesterol transport and retention, abrogate activation of NF-κB and the induction of expression of pro-inflammatory genes induced by hemodynamic forces at atherosclerosis prone regions due to enhanced infiltration by monocytes, CD68+ leukocytes, and macrophages by elaborating factors/molecules that counter pro-atherosclerotic events. Here, NFKB1 is linked to atherosclerosis.