Normocholesterolemic C57BL/6 mice and rabbits showed activation of NF-κB and elevated expression of VCAM-1 and ICAM-1, upregulation of pro-inflammatory genes IL-1, IL-6, MCP-1, as well as antioxidant genes glutathione peroxidase and glutathione-S- transferase 2 in endothelial cells in atherosclerosis-susceptible regions of the ascending aorta [53,71]. The gene discussed is NFKB1; the disease is atherosclerosis.