In the absence of adequate amounts of PUFAs, endothelial cells will not be able to synthesize and release sufficient quantities of PGE1, PGI2, PGI3, lipoxins, resolvins, protectins, maresins and nitrolipids that could lead to endothelial dysfunction, insulin resistance and finally the initiation and progression of the metabolic syndrome and ischemic heart disease. The gene discussed is CD59; the disease is coronary artery disorder.