CRP and hypertensive disorder: To analyze the association of levels of CRP with rs2259816 genotype, we used analysis of variance in which the genotype groups (defined by the presence or the absence of an A-allele) were included as main effects; statistical adjustments were made for age, sex and cardiovascular risk factors, namely body mass index, diabetes mellitus, hypertension, smoking, LDL-C, HDL-C and TG (Figure 1).