In addition, our linkage analysis identified novel regions and putative genes that may also be associated with obesity-related phenotypes including PI4KB, HAAO, CNTN4, GRM7, UFM1, RB1, BOD1L, STARD4, EGLN3 and NRN1. Interestingly, some of these genes appear to play a role in neurological disorders [54], or neuronal development or signaling [55-57], similar to those genes identified recently in the GWAS [12,38]. The gene discussed is CNTN4; the disease is obesity due to melanocortin 4 receptor deficiency.