Analysis of an expression microarray with RNA from 2 NPC cell lines before and after treatment with a demethylating agent 5-aza-2'-deoxycytidine (5-aza-dC) revealed the transcriptional levels of TFPI-2 in both cell lines significantly upregulated after demethylation(unpublished data). This evidence concerns the gene TFPI2 and nasopharyngeal carcinoma.