More recently, factor-inhibiting hypoxia-inducible factor (FIH) was experimentally verified as the target of miR-31 in HNSCC cell and the tumor-suppressive genes, large tumor suppressor 2 (LATS2) and PP2A regulatory subunit B alpha isoform (PPP2R2A) were the targets of miR-31 in lung cancer [11,14]. This evidence concerns the gene LATS2 and head and neck squamous cell carcinoma.