Overall, a number of signaling pathways are consistently and highly enriched across all seven types of cancers, such as Wnt, p53 and integrin signaling pathways, as well as a few other processes like phospho-APC/C-mediated degradation of cyclin A and inflammation determined by chemokine and cytokine signaling pathways (in addition to the general cellular processes such as cell cycle, DNA replication and repair, apoptosis and various metabolic pathways). The gene discussed is TP53; the disease is cancer.