For example, the glutathione metabolic pathway is enriched across five cancer types, excluding breast and prostate cancer; E. coli infection-related pathways are activated in kidney, lung, pancreatic and stomach cancers but not in other cancers; the thyrotropin-releasing hormone receptor signaling pathway is activated in pancreatic and kidney cancer, but not in the other five cancers; and steroid biosynthesis is activated in breast, lung and pancreatic cancer but not in the other four cancers. The gene discussed is TRHR; the disease is familial pancreatic carcinoma.