The best three single-gene discriminators are SERPINH1, BGN and COL12A1 for stomach cancer, having 99.1%, 98.2% and 98.2% classification accuracy on the training set and 94.2% and 96.7%, 88.4% and 93.3%, and 84.1% and 75.8% on the two test sets, respectively. Here, SERPINH1 is linked to gastric cancer.