TOP2A and cancer: For example, CDC2, up-regulated in five of the seven cancers studied, has been reported to be related to colon, prostate and stomach cancer, which is not surprising in view of its role in regulating the cell cycle, e.g. entry from G1 to S; TOP2A, again up-regulated in five of the seven cancers, has been reported to be associated with gastric [51], breast [52] and ovarian cancer [53], consistent with its function in DNA strand regulation; Both of these two genes have been considered as multi-type cancer markers by a previous meta-analysis of cancer microarray data [7].