Similarly, for early breast cancer, the best three k-gene discriminators are {GPR109B, PCOLCE2, PCSK5}, {PCSK5+COL10A1, FERMT2+SPINT2, MAOA+IGJ}, {COL1A1+PCSK5+TF, GPX3+COL1A1+SPINT2, GPX3+FAP+TMEM97}, and {RRM2+COL1A1+GPR109B+IGJ, RRM2+COL1A1+GPR109B+IGJ, RRM2+COL1A1+GPR109B+SPINT2}, respectively. The gene discussed is RRM2; the disease is breast carcinoma.