APC and cancer: Overall, a number of signaling pathways are consistently and highly enriched across all seven types of cancers, such as Wnt, p53 and integrin signaling pathways, as well as a few other processes like phospho-APC/C-mediated degradation of cyclin A and inflammation determined by chemokine and cytokine signaling pathways (in addition to the general cellular processes such as cell cycle, DNA replication and repair, apoptosis and various metabolic pathways).