Of particular interest is the finding that pancreatic cancer has the greatest number of differentially expressed genes, compared to other cancer types, that are involved in a complex network consisting of the EGF signaling pathway, purine and aminosugar metabolism, PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase, metabotropic glutamate receptor group II pathway, Fc epsilon receptor I signaling and the BCR and IL 4 signaling pathways. This evidence concerns the gene EGF and familial pancreatic carcinoma.