We used immunohistochemistry to examine E-cadherin expression in brain tumor and non-neoplastic brain samples from three tissue microarrays (TMAs): two constructed at the Mayo Clinic containing a total of 83 glioblastoma (predominantly) or anaplastic astrocytoma samples and one glioma invasion tissue microarray containing 31 matched brain tumor rim/core samples (a generous gift from M. Berens [34]). Here, CDH1 is linked to central nervous system cancer.