To conclude, our population-based GWAS demonstrate four novel loci on chromosomes 19q13 (within the RASIP1 locus), 6q24 (adjacent to the VTA1 and NMBR loci), 12q24 (in the region of the SH2B3, ATXN2 and PTPN11 loci) and 5q14 (adjacent to the MEF2C locus) associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. Here, SH2B3 is linked to cardiovascular disorder.