BRCA1 and breast cancer: Of the seven GWAS-identified breast cancer-associated SNPs examined in a BRCA2 background [13], [19], [20], SNPS in FGFR2 (rs2981575), TOX3 (rs3803662), MAP3K1 (rs889312), and LSP1 (rs3817198) have been shown to modify BRCA2 penetrance, in contrast with BRCA1 tumors, in which only two of these same SNPs (based on a 2 degrees of freedom model) modified risk of these largely ER-negative tumors [26].