BRCA1 and breast cancer: Similarly, in a recent report of SNPs from sporadic breast cancer GWAS genotyped in a restricted set of BRCA1/2 carriers [27], loci in LOC134997 (rs9393597: per allele HR = 1.55, 95% CI 1.25–1.92, ) and FBXL7 (rs12652447: HR = 1.37, 95% CI 1.16–1.62, ) were associated with BRCA2 breast cancer risk with p-values weaker than FGFR2 reported here (per allele ), although the magnitudes of the associations were slightly stronger than FGFR2 (HR = 1.28).