The hallmark of glioma is increased activity of the PI3K/Akt pathway that controls the expression of pro-survival proteins, including NF-κB (nuclear factor-kappaB), CREB (cAMP response element binding) (CREB) and Bcl-2 as well as pro-apoptotic molecules such as Bax and BAD [14]–[18]. This evidence concerns the gene CREB1 and central nervous system cancer.