A potential role for chromosome 18q in the development of CRC with associated liver metastases has been previously reported [35]; in this regard, decreased expression of Smad4 in addition to DCC, has been pointed out as a potential target protein coded in chromosome 18q since it is associated with both liver and lymph node metastases [36]. This evidence concerns the gene SMAD4 and metastatic malignant neoplasm in the lymph nodes.