Interestingly, several of these small and large altered regions contain cancer-associated genes known to be involved in CRC and/or the metastatic process: i.e. the TPD52[29], FABP5[30], MAP2K4[31], LLGL1[32], FBLN1[33] and TYMP[34] genes. This evidence concerns the gene FBLN1 and colorectal carcinoma.