TNFRSF1A and neoplasm: Among these genes, overexpression of TNFRSF6B -a gene that belongs to the tumor necrosis factor receptor (TNFR) super-family- has been reported in advanced stages of CRC [37] and other tumors of the gastrointestinal tract [41], in association with an increased resistance to adjuvant chemotherapy [42]; in turn, increased NTSR1 expression has been reported as an early event in colon tumorigenesis that contributes to tumor progression and an aggressive clinical behavior [39].