NOTCH2 and cancer: Previous studies suggest that genes typically deregulated by these chromosome breaks included the REG4[53] and NOTCH2[54] genes at chromosome 1p12, EIF4EBP1[55] and FGFR[56] at chromosome 8p12, and the FOXA2[57] gene at chromosome 20p12; all these genes have been associated with the development and progression of CRC and the metastatic process in a variety of human cancers, including the development of liver metastases in CRC [53]–[57].