The proportion of Foxp3+ Treg cells in secondary lymphoid tissues is similar in the NOD mice relative to T1D-resistant C57BL/6 mice While T1 D progression is not attributed to systemic fluctuations in CD4+Foxp3+ Treg cell numbers, there is a paradoxical increase of Treg cells in the pancLN at T1 D onset[8]. The gene discussed is CD4; the disease is type 1 diabetes mellitus.