We further assessed PTCH1 expression in cell lines and samples of both tumor types, and observed that 50% of the samples showed high expression levels of PTCH1. This "mixed-pattern" of PTCH1 expression amongst samples suggests that there may be GLI1 independent regulatory mechanisms, both at the genetic and/or epigenetic level, influencing PTCH1 expression. The gene discussed is PTCH1; the disease is neoplasm.