PTCH1 and astrocytoma (excluding glioblastoma): On the contrary, we observed significant correlation of GLI1 expression with downstream target genes PTCH1 (p = 0.07), Cyclin D2 (p = 0.006), Plakoglobin (p = 0.02), PAX6 (p = 0.006) and NKX.2.2 (p = 0.0001) in astrocytoma cell lines.