In the course of our studies, we sought to understand the regulation of certain downstream target genes of the Shh pathway, including PTCH1, Cyclin D2, Plakoglobin, NKX2.2, and PAX6, in a panel of medulloblastoma and astrocytoma cell lines and tumors. This evidence concerns the gene PTCH1 and astrocytoma (excluding glioblastoma).