TLR4 and colonic neoplasm: Since in previous studies we reported that TLR-4 levels were up-regulated in the thymus of myasthenia gravis patients [44], suggesting an innate-immune mediated priming for subsequent autosensitization to the acetylcholine receptor, we investigated the expression of IL-6 and TLR-4 across a spectrum of tissues recapitulating diverse steps along the evolution towards colon cancer.