SIGIRR and adenocarcinoma: In addition to repressed HGF, we validated the enhancement of TLR-4-bearing and IL-6-secreting cells in adenocarcinoma specimens of colitis-associated cancer developed in mice lacking the expression of Tir8, an inhibitory member of the interleukin-1 receptor family that acts as a negative regulator of NF-κB activation in response to TLRs and interleukin 1 receptor agonists [59].