In particular, we observed that CRC patients (adenocarcinomas, pT1-4) with a percentage of TLR-4+ cells in the tumor stromal compartment lower than the median value (20% of the cells positive) relapsed with a greater time interval and several showed survival of over 100 months, while those patients with a percentage of TLR-4+ cells in the stromal compartment higher than the median value relapsed earlier and fewer showed long term survival (RR 2.36; log rank chi-square 4.25, p < 0.05) (Figure 6a). Here, TLR4 is linked to neoplasm.