PROM1 and neoplasm: Reportedly, CD133 expressing cells in glioblstoma and colorectal cancers include, but are apparently not limited to, the small subpopulation of tumor cells termed as cancer stem cells (CSCs) which mediate tumor initiation, metastasis and recurrence [4-6], and possess the unique self-renewal properties, the multiple differentiating potential, the proliferating aptitude and the carcinogenesis [5,7,8].