Nowadays, CD133 presentation was found in many solid tumors such as brain tumor [4,7], prostate [8], pancreatic [11], hepatocellular [12] and colon cancers [5,6], but the specific role of these CSCs in tumor biology, including metastasis and recurrence, is still uncertain, especially in human GC. The gene discussed is PROM1; the disease is malignant colon neoplasm.