AVPR2 and Sepsis: Whereas particular attention has been paid to the vasoconstriction mediated by vascular V1aRs [3,4], there is increasing evidence that stimulation of extrarenal (endothelial) V2Rs [5-7] may aggravate sepsis-induced vasodilation [4,8], fluid accumulation [9], leukocyte rolling [10], and microvascular thrombosis [11].