In kaolin-mediated severe hydrocephalus in neonatal (one-day old) and juvenile (three weeks old) rats, an intense cerebral, perivascular AQP4 immunostaining was reported at four weeks and nine months post-injection in the juvenile animals, although the study did not find significant AQP4 changes by using WB [18]. The gene discussed is AQP4; the disease is Hydrocephalus.