AQP4 expression was significantly decreased (Kruskal-Wallis) relative to control in both the periventricular region after two days of hydrocephalus (control: 1.00, 0.95-1.04, two day: 0.78, 0.63-0.084, p < 0.05) and in the cortex (control: 1.00, 0.93-1.14, two day: 0.81, 0.67-0.97, p < 0.05) and normalized after one week. Here, AQP4 is linked to Hydrocephalus.