CD8A and cancer: Several studies have demonstrated the presence of TILs in various solid human cancers, most recently showing the association of an abundance of CD3+, CD8+ or CD45RO+ lymphocytic tumor infiltration with a survival benefit for patients with gastric [8] and colorectal [9-11] cancer, as well as for patients with endometrial [12], cervical [13], ovarian [14,15], urothelial [16] and hepatocellular [17] carcinoma and melanoma [18].