In our studies, aberrant cytoplasmic expression of p33ING1b, ING4, and ING5 was detected in 14.5%, 68.8%, and 47.7% in 214 cases of HNSCC, respectively [80, 86, 87], while no or seldom cytoplasmic expression of these ING proteins was detectable in the cases of normal mucosa. The gene discussed is ING1; the disease is head and neck squamous cell carcinoma.