According to recent research, several diagnostic and prognostic markers have been proposed in improving the diagnostic accuracy of papillary thyroid cancer such as Cytokeratin-19 (CK-19), HBME-1, Galectin-3, CD44, CD56, E-cadherin, c-erbB-2, p21cip1, p27kip1, and p16ink4a [4–13]. This evidence concerns the gene CD44 and thyroid gland papillary carcinoma.