EIF2AK3 and osteoporosis: In view of the relatively high prevalence of WRS syndrome evidenced by EIF2AK3 mutations in neonatal/early onset diabetic patients born from consanguineous parents, we recommend systematic sequencing of the coding regions of EIF2AK3 gene in patients born from consanguineous parents, or coming from isolated populations with frequent inbreeding, even in the absence of any evidence of osteoporosis or bone abnormalities at disease onset.