Although hypoglycemia has not been reported in WRS patients before diabetes onset, to our knowledge, we cannot exclude that such episodes may be undiagnosed, in the absence of other clinical manifestations prior to diabetes onset, and may result in early death of these patients before diagnosis, as observed in Perk KO mice in some specific genetic background (D. Cavener, pers. Here, EIF2AK3 is linked to diabetes mellitus.