TGFB1 and neoplasm: Interestingly, we also observed correlations between pathways (IL12, IFNG, IL2) involved in Th1 mediated immune response, as well as correlations between pathways (IL13, TGFB) that act via Th2 immune responses to putatively suppress the tumor inhibitory role of Th1 pathways (Figure 5) [25,26].