TGFB1 and breast carcinoma: Once again we observed that combined high IL12 low TGFB defined a good prognosis subtype in ER- breast cancer (HR = 0.11 (0.01-0.78) P = 0.007, Figure 7C) and that the stratification based on the combined activity levels provided a better stratification than that based on the individual pathways (Additional file 12).