Furthermore, 76.4% of the adoptively transferred cells that were isolated from the adoptive hosts' tDLN 3 days after AIT were CD62L+, which suggested that activation with B/I may stimulate sensitized or CD62L- TEM (CD62L- CCR7low, CD27+, BCL-2 hi) or effector T cells to shift to a CD62L+ TCM phenotype, which we initially supposed would be largely responsible for the anti-tumor effects we have observed. This evidence concerns the gene BCL2 and neoplasm.