In cellular models of Synucleinopathies, ubiquitinated inclusions increase when human α-Synuclein is co-expressed with parkin and synphilin-1, but decrease when phosphorylation of α-Synuclein is blocked by expression of the S129A α-Synuclein mutant [33]. The gene discussed is SNCAIP; the disease is synucleinopathy.