ERBB2 and breast cancer: The Neo-ALTTO trial is a randomized, open-labeled, multicentric, phase III study comparing the efficacy of neoadjuvant lapatinib plus paclitaxel with that of trastuzumab plus paclitaxel and with concomitant lapatinib and trastuzumab plus paclitaxel given as neoadjuvant treatment in HER2-overexpressed operable breast cancer with a tumor diameter >2 cm [69].