Preliminary findings from a phase II study evaluating neratinib at a dose of 240 mg/day in patients with HER2-amplified trastuzumab-naïve or previously treated locally advanced breast cancer or MBC showed that patients in the previously treated group (n = 61) had an ORR of 26% with a median PFS of 23 weeks [72]. Here, ERBB2 is linked to breast carcinoma.