In the case of bladder cancer, loss of E-cadherin expression is a common event [42], which occurs in advanced tumours as a result of CDH1 locus hypermethylation or mutation [39] and there is evidence for a strong association between hypermethylation of the E-cadherin locus with high disease-progression risk [43]. This evidence concerns the gene CDH1 and urinary bladder carcinoma.