We propose that after discovery of severe hyperglycemia in a neonate who is negative for serological markers of type 1 diabetes, a preliminary assessment of abnormalities of chromosome 6q24 can be performed (as at this stage, it is too early to guess NDM will be permanent or transient) followed by the search of a mutation in both KCNJ11 and INS using Sanger sequencing as these two genes can be easily and quickly sequenced. The gene discussed is INS; the disease is type 1 diabetes mellitus.