CBA/J x DBA/2 mice treated with pravastatin did not show hypertension in response to Ang II or wheel running when compared to untreated CBA/J x DBA/2 mice (response to Ang II: 12±3 vs 32±5 mmHg, p<0.01; wheel running: 2±2 vs 15±3 mmHg, p<0.05). The gene discussed is AGT; the disease is hypertensive disorder.